Biweekly newsletter of the International Cytokine & Interferon Society

Immune modulation by the TGFβ superfamily – ICIS supported symposium at BSI 2023 in Belfast, Co-Chair Mark Travis

joefner@cytokinesociety.org

ICIS Supported Parallel Session at BSI 2023 in Belfast

Chairs
  • Joanne Konkel – University of Manchester, UK
  • Mark Travis – University of Manchester, UK
Title:Immune modulation by the TGFβ superfamily
Time:07/12/2023, 11:00 – 12:45
Location:Studio
11:00 – 11:30Antibody-mediated TGF-β1 activation to treat auto- and allo-immune diseases
 Sophie Lucas – Université catholique de Louvain / de Duve Institute, Belgium
11:30 – 11:45The antimicrobial peptide cathelicidin enhances TGF-beta signalling to direct cytotoxic T cell differentiation and effector function
 Jessica Anania – University of Southampton, United Kingdom
11:45 – 12:00Genetic and inflammatory factors regulate monocyte expression of the TGFβ-activating integrin αvβ8 in IBD
 Daniel Brice – University of Manchester, United Kingdom
12:00 – 12:15Unravelling the roles of ILC3-derived TGF-β1 in immune-epithelial interactions.
 Diana Coman – King’s College London, United Kingdom
12:15 – 12:45A modular family of parasite TGF-β mimics mediate cell-specific immune modulation
 Rick Maizels – University of Glasgow, United Kingdom

Organised by BSI Inflammation Affinity Group and BSI Greater Manchester Immunology Group. Supported by the International Cytokine & Interferon Society (ICIS).

Invited speakers
  • Sophie Lucas – UC Louvain, Belgium
  • Rick Maizels – University of Glasgow, UK

Cytokine-mediated regulation is crucial in control of the immune system. The cytokine TGFβ is a vital, widely studied, and fascinating cytokine. Unlike most cytokines, it is secreted as an inactive complex that requires activation extracellularly. It has multiple roles in immunity with cell-type and tissue-specific functions and is a therapeutic target in multiple diseases including cancer, autoimmunity and fibrosis. This session will focus on the immunobiology of TGFβ in different tissue and disease-settings.

 
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