Dr. Zhian (Anthony) Chen has compiled the following review articles of relevance to researchers in the field of cytokine, chemokine and interferon biology. Dr. Chen is a Senior Research Fellow and Group Leader at the University of Queensland Frazer Institute. They lead a team under the UQ Health Research Accelerator (HERA) program to investigate T cell-mediated immunity in the contexts of vaccination, infection, and cancers.
Contextualizing TH17 cells in cancer.
PMID: 41495217
Pang D, Bertocchi A, Powrie F, Pohin M.
Nat Rev Immunol. 2026 Jan 6. doi: 10.1038/s41577-025-01250-6. Online ahead of print.PMID: 41495217 Review.
Regulators of CD8+ T cell exhaustion.
PMID: 41034337
Sun Q, Dong C.
Nat Rev Immunol. 2026 Feb;26(2):129-151. doi: 10.1038/s41577-025-01221-x. Epub 2025 Oct 1.PMID: 41034337 Review.
Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons.
PMID: 41481813
Boehmer D, Ghosh S, Jena KK, Akusjärvi SS, Zanoni I.
Annu Rev Immunol. 2026 Jan 2. doi: 10.1146/annurev-immunol-083024-032807. Online ahead of print.PMID: 41481813 Review.
CX3CL1: a key switch of cell death immunogenicity.
PMID: 40967967
Demuynck R, Naessens F, Krysko DV.
Trends Cancer. 2025 Dec;11(12):1145-1154. doi: 10.1016/j.trecan.2025.08.008. Epub 2025 Sep 17.PMID: 40967967 Review.
Diverse IL-9-secreting T helper cells direct responses in the allergic lung.
PMID: 41539200
Jackson KG, Kaplan MH.
Semin Immunol. 2026 Jan 14;81:102014. doi: 10.1016/j.smim.2026.102014. Online ahead of print.PMID: 41539200 Free article. Review.
Designing immunity with cytokines: A logic-based framework for programmable CAR therapies.
PMID: 40976094
Upadhyay S, Upmanyu K, Gabr MT.
Cytokine Growth Factor Rev. 2025 Dec;86:40-55. doi: 10.1016/j.cytogfr.2025.09.004. Epub 2025 Sep 18.PMID: 40976094 Review.
Anti-cytokine biologics for asthma in adults.
PMID: 41038208
Israel E, Wechsler ME, Jackson DJ, Moore WC.
Lancet. 2025 Nov 8;406(10516):2282-2294. doi: 10.1016/S0140-6736(25)01625-3. Epub 2025 Sep 29.PMID: 41038208 Review.
Inflame and restrain – the paradoxical roles of IL-12 and IL-23 in immunity.
PMID: 41513969
Rindlisbacher L, Navarro MN, Becher B.
Nat Rev Immunol. 2026 Jan 9. doi: 10.1038/s41577-025-01255-1. Online ahead of print.PMID: 41513969 Review.
Interleukin-22: the hub bridging gut homeostasis and metabolism.
PMID: 41266201
Wang S, Gong J, Wang J, Wang WL, Huang LH.
Trends Immunol. 2025 Nov 19:S1471-4906(25)00253-4. doi: 10.1016/j.it.2025.10.009. Online ahead of print.PMID: 41266201 Review.
Post-translational modifications of NLRP3: to prime or not to prime?
PMID: 41219086
Dufies O, Zanoni I.
Trends Immunol. 2025 Nov 10:S1471-4906(25)00252-2. doi: 10.1016/j.it.2025.10.008. Online ahead of print.PMID: 41219086 Free article. Review.
Wiring and rewiring PANoptosis: Molecular vulnerabilities for targeting inflammatory cell death in human disease.
PMID: 40972055
Upmanyu K, Upadhyay S.
Cytokine Growth Factor Rev. 2025 Dec;86:1-16. doi: 10.1016/j.cytogfr.2025.09.003. Epub 2025 Sep 13.PMID: 40972055 Review.
IL-18 in atopic dermatitis-a multifaceted driver of skin inflammation.
PMID: 40783003
Bähler L, Schärli S, Luther F, Bertschi NL, Skabytska Y, Roediger B, Schlapbach C.J Allergy Clin Immunol. 2025 Nov;156(5):1160-1172. doi: 10.1016/j.jaci.2025.07.025. Epub 2025 Aug 7.PMID: 40783003 Free article. Review.
Interferons in health and disease.
PMID: 40845809
Boehmer D, Zanoni I.
Cell. 2025 Aug 21;188(17):4480-4504. doi: 10.1016/j.cell.2025.06.044.PMID: 40845809 Review.
Leptin: 30 Years Later.
PMID: 41043250
Ahima RS, Flier JS.
Annu Rev Physiol. 2025 Oct 3. doi: 10.1146/annurev-physiol-042324-100259. Online ahead of print.PMID: 41043250 Review.
Reframing IL-27: a central regulator of CD8+ T cell immunity.
PMID: 41266200
Venzin V, Iannacone M.
Trends Immunol. 2025 Nov 20:S1471-4906(25)00269-8. doi: 10.1016/j.it.2025.10.012. Online ahead of print.PMID: 41266200 Free article. Review.
Unlocking IL-18: A hidden key in cancer immunity.
PMID: 41056758
Sepehri-Manesh S, Debeaud M, Vouret-Craviari V.
Semin Immunol. 2025 Dec;80:101997. doi: 10.1016/j.smim.2025.101997. Epub 2025 Oct 6.PMID: 41056758 Free article. Review.
IL-1 family cytokines in inflammation and immunity.
PMID: 41087719
Garlanda C, Di Ceglie I, Jaillon S.
Cell Mol Immunol. 2025 Nov;22(11):1345-1362. doi: 10.1038/s41423-025-01358-8. Epub 2025 Oct 14.PMID: 41087719 Free PMC article. Review.
Bidirectional Communication Between the Innate and Adaptive Immune Systems.
PMID: 40279312
Warrick KA, Vallez CN, Meibers HE, Pasare C.
Annu Rev Immunol. 2025 Apr;43(1):489-514. doi: 10.1146/annurev-immunol-083122-040624. PMID: 40279312 Free PMC article. Review.
Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities.
PMID: 40102163
Mendes-Monteiro L, Viejo-Borbolla A.
Trends Immunol. 2025 Apr;46(4):284-294. doi: 10.1016/j.it.2025.02.013. Epub 2025 Mar 18. PMID: 40102163 Free article. Review.
Gasdermins in pyroptosis, inflammation, and cancer.
PMID: 40307076
Min R, Bai Y, Wang NR, Liu X.
Trends Mol Med. 2025 Apr 29:S1471-4914(25)00090-5. doi: 10.1016/j.molmed.2025.04.003. Online ahead of print. PMID: 40307076 Review.
IL-1β+ macrophages and the control of pathogenic inflammation in cancer.
PMID: 40169292
Caronni N, La Terza F, Frosio L, Ostuni R.
Trends Immunol. 2025 May;46(5):403-415. doi: 10.1016/j.it.2025.03.001. Epub 2025 Mar 31.PMID: 40169292 Review.
Lactate: A key regulator of the immune response.
PMID: 40073846
Llibre A, Kucuk S, Gope A, Certo M, Mauro C.
Immunity. 2025 Mar 11;58(3):535-554. doi: 10.1016/j.immuni.2025.02.008. PMID: 40073846 Free article. Review.
The epigenetic landscape of fate decisions in T cells.
PMID: 40108419
Jay A, Pondevida CM, Vahedi G.
Nat Immunol. 2025 Apr;26(4):544-556. doi: 10.1038/s41590-025-02113-x. Epub 2025 Mar 19.PMID: 40108419 Review.
Cutaneous T cell immunity.
PMID: 40335684
Zareie P, Weiss ES, Kaplan DH, Mackay LK.
Nat Immunol. 2025 May 7. doi: 10.1038/s41590-025-02145-3. Online ahead of print.PMID: 40335684 Review.
Cross-regulation between the nervous system and type 2 immunity.
PMID: 40378238
Mroz NM, Chiaranunt P, Molofsky AV, Molofsky AB.
Sci Immunol. 2025 May 16;10(107):eadp6450. doi: 10.1126/sciimmunol.adp6450. Epub 2025 May 16.PMID: 40378238 Review.
Human immunity to fungal infections.
PMID: 40232283
Vinh DC.
J Exp Med. 2025 Jun 2;222(6):e20241215. doi: 10.1084/jem.20241215. Epub 2025 Apr 15.PMID: 40232283 Free article. Review.
Interferon regulatory factor 3 beyond innate immunity: Regulation in obesity and metabolic disorders.
PMID: 40156960
Li H, Zhang Y, Peh HY.
Semin Immunol. 2025 Jun;78:101948. doi: 10.1016/j.smim.2025.101948. Epub 2025 Mar 28.PMID: 40156960 Free article. Review.
Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma.
PMID: 40116139
Latayan J, Akkenapally SV, Madala SK.
Immunol Rev. 2025 Mar;330(1):e70020. doi: 10.1111/imr.70020.PMID: 40116139 Free PMC article. Review.
Coordinated Regulation of Extrafollicular B Cell Responses by IL-12 and IFNγ.
PMID: 40211749
Elsner RA, Shlomchik MJ.
Immunol Rev. 2025 May;331(1):e70027. doi: 10.1111/imr.70027.PMID: 40211749 Free PMC article. Review.
Soluble Factors and Mechanisms Regulated by Sialylated IgG Signaling.
PMID: 40084926
Edwards DL, Huang M, Wang TT.
Immunol Rev. 2025 Mar;330(1):e70021. doi: 10.1111/imr.70021.PMID: 40084926 Review.
T cell-B cell interactions in human autoimmune diseases.
PMID: 40020254
Sowerby JM, Rao DA.
Curr Opin Immunol. 2025 Apr;93:102539. doi: 10.1016/j.coi.2025.102539. Epub 2025 Feb 27.PMID: 40020254 Review.
Metabolism and metabolites regulating hematopoiesis.
PMID: 39827832
Zhang B, Fagarasan S.
Curr Opin Immunol. 2025 Apr;93:102525. doi: 10.1016/j.coi.2025.102525. Epub 2025 Jan 18.PMID: 39827832 Review.
Targeting alarmins in asthma: From bench to clinic.
PMID: 39855362
Akenroye A, Boyce JA, Kita H.
J Allergy Clin Immunol. 2025 Apr;155(4):1133-1148. doi: 10.1016/j.jaci.2025.01.017. Epub 2025 Jan 22.PMID: 39855362 Review.
Engineering cytokines for tumor-targeting and selective T cell activation.
PMID: 39955218
Peng K, Fu YX, Liang Y.
Trends Mol Med. 2025 Apr;31(4):373-387. doi: 10.1016/j.molmed.2025.01.010. Epub 2025 Feb 14.PMID: 39955218 Review.
TNF/TNFR Superfamily Members in Costimulation of T Cell Responses-Revisited.
PMID: 39745933
Watts TH, Yeung KKM, Yu T, Lee S, Eshraghisamani R.
Annu Rev Immunol. 2025 Apr;43(1):113-142. doi: 10.1146/annurev-immunol-082423-040557. Epub 2025 Jan 2.PMID: 39745933 Free article. Review.
Malignant JAK-signaling: at the interface of inflammation and malignant transformation.
PMID: 40140631
Perner F, Pahl HL, Zeiser R, Heidel FH.
Leukemia. 2025 May;39(5):1011-1030. doi: 10.1038/s41375-025-02569-8. Epub 2025 Mar 26.PMID: 40140631 Free PMC article. Review.
Thymic Interferons: A Little Goes a Long Way.
PMID: 40439345
Vobořil M, Hogquist KA.
Immunol Rev. 2025 Jul;332(1):e70038. doi: 10.1111/imr.70038.PMID: 40439345 Review.
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine.
PMID: 40044530
Shojaei M, McLean AS.
Trends Immunol. 2025 Mar;46(3):219-228. doi: 10.1016/j.it.2025.01.008. Epub 2025 Mar 4.PMID: 40044530 Free article. Review.
Targeted protein degradation for cancer therapy.
PMID: 40281114
Hinterndorfer M, Spiteri VA, Ciulli A, Winter GE.
Nat Rev Cancer. 2025 Apr 25. doi: 10.1038/s41568-025-00817-8. Online ahead of print.PMID: 40281114 Review.
Neurons as Immunomodulators: From Rapid Neural Activity to Prolonged Regulation of Cytokines and Microglia.
PMID: 39805040
Wood LB, Singer AC.
Annu Rev Biomed Eng. 2025 May;27(1):55-72. doi: 10.1146/annurev-bioeng-110122-120158. Epub 2025 Jan 13.PMID: 39805040 Free article. Review.
Controlling pyroptosis through post-translational modifications of gasdermin D.
PMID: 40199241
Zhang N, Xu D.
Dev Cell. 2025 Apr 7;60(7):994-1007. doi: 10.1016/j.devcel.2025.02.005.PMID: 40199241 Review.
Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions.
PMID: 40338831
Awad W, Abdelaal MR, Letoga V, McCluskey J, Rossjohn J.
Immunol Rev. 2025 May;331(1):e70033. doi: 10.1111/imr.70033.PMID: 40338831 Free PMC article. Review.
The diversity of CD8+ T cell dysfunction in cancer and viral infection.
PMID: 40216888
Galluzzi L, Smith KN, Liston A, Garg AD.
Nat Rev Immunol. 2025 Apr 11. doi: 10.1038/s41577-025-01161-6. Online ahead of print.PMID: 40216888 Review.
Immunocytokines and cytokine neutralization for cancer immunotherapy.
PMID: 40425444
Berraondo P, Cuesta R, Aranda F, Martinez-Riaño A, Eguren-Santamaria I, Luri-Rey C, Risson A, Melero A, Gomis G, Melero I.
Trends Cancer. 2025 May 26:S2405-8033(25)00110-4. doi: 10.1016/j.trecan.2025.04.014. Online ahead of print.PMID: 40425444 Review.
The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation.
PMID: 40247142
Polonio CM, McHale KA, Sherr DH, Rubenstein D, Quintana FJ.
Nat Rev Drug Discov. 2025 Apr 17. doi: 10.1038/s41573-025-01172-x. Online ahead of print.PMID: 40247142 Review.
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities.
PMID: 40181165
Llorente A, Arora GK, Murad R, Emerling BM.
Nat Rev Cancer. 2025 Jun;25(6):463-487. doi: 10.1038/s41568-025-00810-1. Epub 2025 Apr 3.PMID: 40181165 Review.
The stress and the alarmin-like cytokine interleukin-37 mediated extracellular and intracellular signal pathways.
PMID: 40209639
Li Y, Chen N, Guo Y, Zhang L.
Semin Immunol. 2025 Jun;78:101952. doi: 10.1016/j.smim.2025.101952. Epub 2025 Apr 12.PMID: 40209639 Review.
Inhibitory pattern recognition receptors: lessons from LAIR1.
PMID: 40425821
Pascoal Ramos MI, van der Vlist M, Meyaard L.
Nat Rev Immunol. 2025 May 27. doi: 10.1038/s41577-025-01181-2. Online ahead of print.PMID: 40425821 Review.
Induced proximity at the cell surface.
PMID: 40140559
Till NA, Ramanathan M, Bertozzi CR.
Nat Biotechnol. 2025 May;43(5):702-711. doi: 10.1038/s41587-025-02592-1. Epub 2025 Mar 26.PMID: 40140559 Review.
Cholinergic T cells revitalize the tumor immune microenvironment: TIME to ChAT.
PMID: 40307453
Zheng C, Liu S, Fazel Modares N, St Paul M, Mak TW.
Nat Immunol. 2025 May;26(5):665-677. doi: 10.1038/s41590-025-02144-4. Epub 2025 Apr 30.PMID: 40307453 Review.
Gasdermins as evolutionarily conserved executors of inflammation and cell death.
PMID: 39187689
Chen KW, Broz P.
Nat Cell Biol. 2024 Sep;26(9):1394-1406. doi: 10.1038/s41556-024-01474-z. Epub 2024 Aug 26.PMID: 39187689 Review.
Exploiting ferroptosis vulnerabilities in cancer.
PMID: 38858502
Nakamura T, Conrad M.
Nat Cell Biol. 2024 Sep;26(9):1407-1419. doi: 10.1038/s41556-024-01425-8. Epub 2024 Jun 10.PMID: 38858502 Review.
Mitochondria and cell death.
PMID: 38902422
Glover HL, Schreiner A, Dewson G, Tait SWG.
Nat Cell Biol. 2024 Sep;26(9):1434-1446. doi: 10.1038/s41556-024-01429-4. Epub 2024 Jun 20.PMID: 38902422 Review.
BCR signaling in germinal center B cell selection.
PMID: 39168721
Inoue T, Baba Y, Kurosaki T.
Trends Immunol. 2024 Sep;45(9):693-704. doi: 10.1016/j.it.2024.07.005. Epub 2024 Aug 20.PMID: 39168721 Review.
The complexity of immune evasion mechanisms throughout the metastatic cascade.
PMID: 39285252
Haynes NM, Chadwick TB, Parker BS.
Nat Immunol. 2024 Oct;25(10):1793-1808. doi: 10.1038/s41590-024-01960-4. Epub 2024 Sep 16.PMID: 39285252 Review.
Ironing out the role of ferroptosis in immunity.
PMID: 38749397
Bell HN, Stockwell BR, Zou W.
Immunity. 2024 May 14;57(5):941-956. doi: 10.1016/j.immuni.2024.03.019.PMID: 38749397 Review.
Antibody modulation of B cell responses-Incorporating positive and negative feedback.
PMID: 38986442
Cyster JG, Wilson PC.
Immunity. 2024 Jul 9;57(7):1466-1481. doi: 10.1016/j.immuni.2024.06.009.PMID: 38986442 Review.
The balance of STING signaling orchestrates immunity in cancer.
PMID: 38918609
Lanng KRB, Lauridsen EL, Jakobsen MR.
Nat Immunol. 2024 Jul;25(7):1144-1157. doi: 10.1038/s41590-024-01872-3. Epub 2024 Jun 25.PMID: 38918609 Review.
The ouroboros of autoimmunity.
PMID: 38698239
Casanova JL, Peel J, Donadieu J, Neehus AL, Puel A, Bastard P.
Nat Immunol. 2024 May;25(5):743-754. doi: 10.1038/s41590-024-01815-y. Epub 2024 May 2.PMID: 38698239 Review.
T cell dysfunction and therapeutic intervention in cancer.
PMID: 39025962
Zebley CC, Zehn D, Gottschalk S, Chi H.
Nat Immunol. 2024 Aug;25(8):1344-1354. doi: 10.1038/s41590-024-01896-9. Epub 2024 Jul 18.PMID: 39025962 Review.
The CD4 Versus CD8 T Cell Fate Decision: A Multiomics-Informed Perspective.
PMID: 38271641
Steier Z, Kim EJY, Aylard DA, Robey EA.
Annu Rev Immunol. 2024 Jun;42(1):235-258. doi: 10.1146/annurev-immunol-083122-040929. Epub 2024 Jun 14.PMID: 38271641 Free article. Review.
The Immunobiology and Treatment of Food Allergy.
PMID: 38360544
Barshow S, Tirumalasetty J, Sampath V, Zhou X, Seastedt H, Schuetz J, Nadeau K.
Annu Rev Immunol. 2024 Jun;42(1):401-425. doi: 10.1146/annurev-immunol-090122-043501. Epub 2024 Jun 14.PMID: 38360544 Free article. Review.
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases.
PMID: 39367124
Dong M, Fitzgerald KA.
Nat Immunol. 2024 Oct 4. doi: 10.1038/s41590-024-01966-y. Online ahead of print.PMID: 39367124 Review.
Kidney-Specific Interleukin-17 Responses During Infection and Injury.
PMID: 37906942
Peroumal D, Biswas PS.
Annu Rev Immunol. 2024 Jun;42(1):35-55. doi: 10.1146/annurev-immunol-052523-015141. Epub 2024 Jun 14.PMID: 37906942 Free article. Review.
T Follicular Helper Cell Heterogeneity.
PMID: 38060987
Song W, Craft J.
Annu Rev Immunol. 2024 Jun;42(1):127-152. doi: 10.1146/annurev-immunol-090222-102834. Epub 2024 Jun 14.PMID: 38060987 Free article. Review.
PMID: 38166256
Baessler A, Vignali DAA.
Annu Rev Immunol. 2024 Jun;42(1):179-206. doi: 10.1146/annurev-immunol-090222-110914. Epub 2024 Jun 14.PMID: 38166256 Free article. Review.
From periphery to center stage: 50 years of advancements in innate immunity.
PMID: 38670064
Carpenter S, O’Neill LAJ.
Cell. 2024 Apr 25;187(9):2030-2051. doi: 10.1016/j.cell.2024.03.036.PMID: 38670064 Free article. Review.
Principles and therapeutic applications of adaptive immunity.
PMID: 38670065
Chi H, Pepper M, Thomas PG.
Cell. 2024 Apr 25;187(9):2052-2078. doi: 10.1016/j.cell.2024.03.037.PMID: 38670065 Free PMC article. Review.
Mechanisms of long COVID and the path toward therapeutics.
PMID: 39326415
Peluso MJ, Deeks SG.
Cell. 2024 Oct 3;187(20):5500-5529. doi: 10.1016/j.cell.2024.07.054. Epub 2024 Sep 25.PMID: 39326415 Free article. Review.
Targeting cytokine networks in neuroinflammatory diseases.
PMID: 39261632
Becher B, Derfuss T, Liblau R.
Nat Rev Drug Discov. 2024 Sep 11. doi: 10.1038/s41573-024-01026-y. Online ahead of print.PMID: 39261632 Review.
Targeting ROS in cancer: rationale and strategies.
PMID: 38982305
Glorieux C, Liu S, Trachootham D, Huang P.
Nat Rev Drug Discov. 2024 Aug;23(8):583-606. doi: 10.1038/s41573-024-00979-4. Epub 2024 Jul 9.PMID: 38982305 Review.
Targeting immunogenic cell stress and death for cancer therapy.
PMID: 38622310
Galluzzi L, Guilbaud E, Schmidt D, Kroemer G, Marincola FM.
Nat Rev Drug Discov. 2024 Jun;23(6):445-460. doi: 10.1038/s41573-024-00920-9. Epub 2024 Apr 15.PMID: 38622310 Free PMC article. Review.