Targeting EGFRvIII and CD47-SIRPα: A New CAR-T Strategy for Glioblastoma Treatment Review contributed by: PhD candidate Eugenio Contreras Castillo (one of the 2024 ICIS-Pfizer Trainee Award Winners for Most Promising Research Presentations at Cytokines 2024), Department of Cell Biology Institute of Cellular Physiology (IFC), National Autonomous University of Mexico (UNAM) [READ MORE]
Photo Credit: Burcu Elmas (pexels.com 10051526) A guide to adaptive immune memory.PMID: 38831162Lam N, Lee Y, Farber DL.Nat Rev Immunol. 2024 Jun 3. doi: 10.1038/s41577-024-01040-6. Online ahead of print.PMID: 38831162 Review. Towards a unifying model for B-cell receptor triggering.PMID: 39256626Degn SE, Tolar P.Nat Rev Immunol. 2024 Sep 10. doi: 10.1038/s41577-024-01073-x. Online ahead [READ MORE]
In the Phase 2 CITYSCAPE trial, Tiragolumab, an anti-TIGIT antibody, demonstrated efficacy when combined with Atezolizumab, an anti-PD-L1, compared to Atezolizumab alone for the treatment of non-small cell lung carcinoma. In mouse models, inhibition of both the TIGIT and PD-1 pathways was shown to synergistically function to reinvigorate T cell [READ MORE]
April 17, 2024 – Reviews of Interest PMID: 37726402 Anti-cytokine autoantibodies: mechanistic insights and disease associations. Cheng A, Holland SM. Nat Rev Immunol. 2024 Mar;24(3):161-177. doi: 10.1038/s41577-023-00933-2. Epub 2023 Sep 19.PMID: 37726402 Review. This review provides a comprehensive overview of the emerging field of anti-cytokine autoantibodies (ACAA), including their pathological [READ MORE]
COVID-19 special: PMID: 36198912 COVID-19 and cellular senescence. Schmitt CA, Tchkonia T, Niedernhofer LJ, Robbins PD, Kirkland JL, Lee S. Nat Rev Immunol. 2022 Oct 5:1-13. doi: 10.1038/s41577-022-00785-2. Online ahead of print.PMID: 36198912 Free PMC article. Review. PMID: 36631691 Innate immune evasion strategies of SARS-CoV-2. Minkoff JM, tenOever B. Nat Rev Microbiol. [READ MORE]
COVID-19 special: PMID: 36198912 COVID-19 and cellular senescence. Schmitt CA, Tchkonia T, Niedernhofer LJ, Robbins PD, Kirkland JL, Lee S. Nat Rev Immunol. 2022 Oct 5:1-13. doi: 10.1038/s41577-022-00785-2. Online ahead of print.PMID: 36198912 Free PMC article. Review. PMID: 36631691 Innate immune evasion strategies of SARS-CoV-2. Minkoff JM, tenOever B. Nat Rev Microbiol. 2023 [READ MORE]
Reviews of Interest to cytokine biologists. [READ MORE]
Reviews of interest related to COVID-19 and cytokine biology [READ MORE]
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