New Checkpoint in TLR7/8 Sensing Rewrites Innate Immune Rules
A recent study by Alharbi et.al. from the Gantier Lab published in Nature Immunology, “2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity”, showed that TLR7 and TLR8 sensing is kept in check by naturally occurring 2′-O-methyl (2′-OMe)-modified ribosomal RNA fragments, avoiding autoimmune responses to host RNA in the [READ MORE]