REVIEWS OF INTEREST

By Zhian Chen and Di Yu

PMID: 34002066

Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy.

Morris EC, Neelapu SS, Giavridis T, Sadelain M.

Nat Rev Immunol. 2021 May 17:1-12. doi: 10.1038/s41577-021-00547-6. Online ahead of print.PMID: 34002066 Free PMC article. Review.

PMID: 34155388

Interferon-γ: teammate or opponent in the tumour microenvironment?

Gocher AM, Workman CJ, Vignali DAA.

Nat Rev Immunol. 2021 Jun 21. doi: 10.1038/s41577-021-00566-3. Online ahead of print.PMID: 34155388 Review.

PMID: 34226727

Insights into the biology and therapeutic implications of TNF and regulatory T cells.

Salomon BL.

Nat Rev Rheumatol. 2021 Aug;17(8):487-504. doi: 10.1038/s41584-021-00639-6. Epub 2021 Jul 5.PMID: 34226727 Review.

PMID: 33907323

Interferon lambda in inflammation and autoimmune rheumatic diseases.

Goel RR, Kotenko SV, Kaplan MJ.

Nat Rev Rheumatol. 2021 Jun;17(6):349-362. doi: 10.1038/s41584-021-00606-1. Epub 2021 Apr 27.PMID: 33907323 Free PMC article. Review.

PMID: 34354255

Trends in kinase drug discovery: targets, indications and inhibitor design.

Attwood MM, Fabbro D, Sokolov AV, Knapp S, Schiöth HB.

Nat Rev Drug Discov. 2021 Aug 5. doi: 10.1038/s41573-021-00252-y. Online ahead of print.PMID: 34354255 Review.

PMID: 34083781

Interleukins in cancer: from biology to therapy.

Briukhovetska D, Dörr J, Endres S, Libby P, Dinarello CA, Kobold S.

Nat Rev Cancer. 2021 Aug;21(8):481-499. doi: 10.1038/s41568-021-00363-z. Epub 2021 Jun 3.PMID: 34083781 Free PMC article. Review.

PMID: 33872590

Interleukin-6: obstacles to targeting a complex cytokine in critical illness.

McElvaney OJ, Curley GF, Rose-John S, McElvaney NG.

Lancet Respir Med. 2021 Jun;9(6):643-654. doi: 10.1016/S2213-2600(21)00103-X. Epub 2021 Apr 16.PMID: 33872590 Free PMC article. Review.

PMID: 33838745

Chemokines and the immune response to cancer.

Ozga AJ, Chow MT, Luster AD.

Immunity. 2021 May 11;54(5):859-874. doi: 10.1016/j.immuni.2021.01.012. Epub 2021 Apr 10.PMID: 33838745 Review.

PMID: 34217595

The ‘cytokine storm’: molecular mechanisms and therapeutic prospects.

Karki R, Kanneganti TD.

Trends Immunol. 2021 Aug;42(8):681-705. doi: 10.1016/j.it.2021.06.001. Epub 2021 Jul 1.PMID: 34217595 Review.

PMID: 33972167

Cytokine-skewed Tfh cells: functional consequences for B cell help.

Olatunde AC, Hale JS, Lamb TJ.

Trends Immunol. 2021 Jun;42(6):536-550. doi: 10.1016/j.it.2021.04.006. Epub 2021 May 8.PMID: 33972167 Review.

PMID: 34266767

LFA-1 in T cell priming, differentiation, and effector functions.

Gérard A, Cope AP, Kemper C, Alon R, Köchl R.

Trends Immunol. 2021 Aug;42(8):706-722. doi: 10.1016/j.it.2021.06.004. Epub 2021 Jul 12.PMID: 34266767 Review.

PMID: 33756119

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family.

Katsuno Y, Derynck R.

Dev Cell. 2021 Mar 22;56(6):726-746. doi: 10.1016/j.devcel.2021.02.028.PMID: 33756119 Review.

PMID: 33822846

The metabolism-modulating activity of IL-17 signaling in health and disease.

Bechara R, McGeachy MJ, Gaffen SL.

J Exp Med. 2021 May 3;218(5):e20202191. doi: 10.1084/jem.20202191.PMID: 33822846

PMID: 33544244

Cytokine “fine tuning” of enthesis tissue homeostasis as a pointer to spondyloarthritis pathogenesis with a focus on relevant TNF and IL-17 targeted therapies.

Russell T, Bridgewood C, Rowe H, Altaie A, Jones E, McGonagle D.

Semin Immunopathol. 2021 Apr;43(2):193-206. doi: 10.1007/s00281-021-00836-1. Epub 2021 Feb 5.PMID: 33544244 Free PMC article. Review.

PMID: 34021269

Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor.

Robert M, Miossec P.

Cell Mol Immunol. 2021 Jul;18(7):1644-1651. doi: 10.1038/s41423-021-00694-9. Epub 2021 May 21.PMID: 34021269 Review.

PMID: 33684633

Cytokine engineering for targeted cancer immunotherapy.

Bonati L, Tang L.

Curr Opin Chem Biol. 2021 Jun;62:43-52. doi: 10.1016/j.cbpa.2021.01.007. Epub 2021 Mar 6.PMID: 33684633 Review.

PMID: 34079547

Quantification of Cytokine Storms During Virus Infections.

Yuan S, Jiang SC, Zhang ZW, Fu YF, Hu J, Li ZL.

Front Immunol. 2021 May 17;12:659419. doi: 10.3389/fimmu.2021.659419. eCollection 2021.PMID: 34079547 Free PMC article. Review.

PMID: 34084159

Novel Anti-Cytokine Strategies for Prevention and Treatment of Respiratory Allergic Diseases.

Gubernatorova EO, Namakanova OA, Gorshkova EA, Medvedovskaya AD, Nedospasov SA, Drutskaya MS.

Front Immunol. 2021 May 18;12:601842. doi: 10.3389/fimmu.2021.601842. eCollection 2021.PMID: 34084159 Free PMC article. Review.

PMID: 34177932

Engineered Cytokine Signaling to Improve CAR T Cell Effector Function.

Bell M, Gottschalk S.

Front Immunol. 2021 Jun 4;12:684642. doi: 10.3389/fimmu.2021.684642. eCollection 2021.PMID: 34177932 Free PMC article. Review.

PMID: 34044328

Inborn errors of IL-6 family cytokine responses.

Chen YH, Spencer S, Laurence A, Thaventhiran JE, Uhlig HH.

Curr Opin Immunol. 2021 May 24;72:135-145. doi: 10.1016/j.coi.2021.04.007. Online ahead of print.PMID: 34044328 Review.

PMID: 34299273

Cytokine Release Syndrome Associated with T-Cell-Based Therapies for Hematological Malignancies: Pathophysiology, Clinical Presentation, and Treatment.

Cosenza M, Sacchi S, Pozzi S.

Int J Mol Sci. 2021 Jul 17;22(14):7652. doi: 10.3390/ijms22147652.PMID: 34299273 Free PMC article. Review.

PMID: 33847763

Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease.

Lau SF, Fu AKY, Ip NY.

Cell Mol Life Sci. 2021 May;78(10):4703-4712. doi: 10.1007/s00018-021-03810-0. Epub 2021 Apr 13.PMID: 33847763 Free PMC article. Review.

PMID: 34141712

Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors.

Schmidt-Arras D, Rose-John S.

Front Cell Dev Biol. 2021 Jun 1;9:688314. doi: 10.3389/fcell.2021.688314. eCollection 2021.PMID: 34141712 Free PMC article. Review.

PMID: 33649606

Neuromodulation by the immune system: a focus on cytokines.

Salvador AF, de Lima KA, Kipnis J.

Nat Rev Immunol. 2021 Mar 1. doi: 10.1038/s41577-021-00508-z. Online ahead of print.PMID: 33649606 Review.

PMID: 33686279

TNF in the era of immune checkpoint inhibitors: friend or foe?

Chen AY, Wolchok JD, Bass AR.

Nat Rev Rheumatol. 2021 Mar 8. doi: 10.1038/s41584-021-00584-4. Online ahead of print.PMID: 33686279 Review.

PMID: 33515492

Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis.

Ghoreschi K, Balato A, Enerbäck C, Sabat R.

Lancet. 2021 Feb 20;397(10275):754-766. doi: 10.1016/S0140-6736(21)00184-7. Epub 2021 Jan 27.PMID: 33515492 Review.

PMID: 33428453

Cytokine Regulation and Function in T Cells.

Dong C.

Annu Rev Immunol. 2021 Jan 11. doi: 10.1146/annurev-immunol-061020-053702. Online ahead of print.PMID: 33428453

PMID: 33577346

IL-17 in the Pathogenesis of Disease: Good Intentions Gone Awry.

Majumder S, McGeachy MJ.

Annu Rev Immunol. 2021 Feb 12. doi: 10.1146/annurev-immunol-101819-092536. Online ahead of print.PMID: 33577346

PMID: 33264572

Opposing Roles of Type I Interferons in Cancer Immunity.

Boukhaled GM, Harding S, Brooks DG.

Annu Rev Pathol. 2021 Jan 24;16:167-198. doi: 10.1146/annurev-pathol-031920-093932. Epub 2020 Dec 2.PMID: 33264572

PMID: 33158368

Engineering IL-2 to Give New Life to T Cell Immunotherapy.

Overwijk WW, Tagliaferri MA, Zalevsky J.

Annu Rev Med. 2021 Jan 27;72:281-311. doi: 10.1146/annurev-med-073118-011031. Epub 2020 Nov 6.PMID: 33158368

PMID: 33622601

Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation.

King C, Sprent J.

Trends Immunol. 2021 Feb 12:S1471-4906(21)00027-2. doi: 10.1016/j.it.2021.02.003. Online ahead of print.PMID: 33622601 Free PMC article. Review.

PMID: 33546974

Impact of Type I Interferons on Susceptibility to Bacterial Pathogens.

Peignier A, Parker D.

Trends Microbiol. 2021 Feb 2:S0966-842X(21)00009-3. doi: 10.1016/j.tim.2021.01.007. Online ahead of print.PMID: 33546974 Review.

PMID: 33478870

Roles of TGF-β Superfamily Proteins in Extravillous Trophoblast Invasion.

Li Y, Yan J, Chang HM, Chen ZJ, Leung PCK.

Trends Endocrinol Metab. 2021 Mar;32(3):170-189. doi: 10.1016/j.tem.2020.12.005.PMID: 33478870 Review.

PMID: 33358571

Targeting CTGF in Cancer: An Emerging Therapeutic Opportunity.

Shen YW, Zhou YD, Chen HZ, Luan X, Zhang WD.

Trends Cancer. 2020 Dec 23:S2405-8033(20)30312-5. doi: 10.1016/j.trecan.2020.12.001. Online ahead of print.PMID: 33358571 Review.

PMID: 33172749

Insights Into Mechanisms of GDF15 and Receptor GFRAL: Therapeutic Targets.

Rochette L, Zeller M, Cottin Y, Vergely C.

Trends Endocrinol Metab. 2020 Dec;31(12):939-951. doi: 10.1016/j.tem.2020.10.004. Epub 2020 Nov 7.PMID: 33172749 Review.

PMID: 33692481

Local and systemic effects of IL-17 in joint inflammation: a historical perspective from discovery to targeting.

Miossec P.

Cell Mol Immunol. 2021 Mar 10. doi: 10.1038/s41423-021-00644-5. Online ahead of print.PMID: 33692481 Review.

PMID: 33039897

Cytokines and transcription factors in the differentiation of CD4+ T helper cell subsets and induction of tissue inflammation and autoimmunity.

Pawlak M, Ho AW, Kuchroo VK.

Curr Opin Immunol. 2020 Dec;67:57-67. doi: 10.1016/j.coi.2020.09.001. Epub 2020 Oct 8.PMID: 33039897 Review.

PMID: 32173514

The cytokine network in the pathogenesis of major depressive disorder. Close to translation?

Petralia MC, Mazzon E, Fagone P, Basile MS, Lenzo V, Quattropani MC, Di Nuovo S, Bendtzen K, Nicoletti F.

Autoimmun Rev. 2020 May;19(5):102504. doi: 10.1016/j.autrev.2020.102504. Epub 2020 Mar 13.PMID: 32173514 Review.

PMID: 33482337

Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases.

Cavalli G, Colafrancesco S, Emmi G, Imazio M, Lopalco G, Maggio MC, Sota J, Dinarello CA.

Autoimmun Rev. 2021 Mar;20(3):102763. doi: 10.1016/j.autrev.2021.102763. Epub 2021 Jan 20.PMID: 33482337 Review.

PMID: 33476812

Pathophysiologic role of Interleukin-33/ST2 in Sjögren’s syndrome.

Soyfoo MS, Nicaise C.

Autoimmun Rev. 2021 Mar;20(3):102756. doi: 10.1016/j.autrev.2021.102756. Epub 2021 Jan 18.PMID: 33476812 Review.

PMID: 33485992

Exploring IL-17 in spondyloarthritis for development of novel treatments and biomarkers.

Groen SS, Sinkeviciute D, Bay-Jensen AC, Thudium CS, Karsdal MA, Thomsen SF, Schett G, Nielsen SH.

Autoimmun Rev. 2021 Mar;20(3):102760. doi: 10.1016/j.autrev.2021.102760. Epub 2021

PMID: 33333233

B cell activating factor (BAFF): Structure, functions, autoimmunity and clinical implications in Systemic Lupus Erythematosus (SLE).

Möckel T, Basta F, Weinmann-Menke J, Schwarting A.

Autoimmun Rev. 2021 Feb;20(2):102736. doi: 10.1016/j.autrev.2020.102736. Epub 2020 Dec 14.PMID: 33333233 Review.

PMID: 33542718 

Shared and Unique Features of Human InterferonBeta and InterferonAlpha Subtypes.

Wittling MC, Cahalan SR, Levenson EA, Rabin RL.Front Immunol. 2021 Jan 19;11:605673. doi: 10.3389/fimmu.2020.605673. eCollection 2020.PMID: 33542718 Free PMC article. Review.

Bronze Sponsor of Cytokines 2021 Hybrid Meeting