I am Arnaud Huard, a French postdoctoral researcher at the University of Geneva, Switzerland. I finished and successfully defended my PhD at the beginning of 2021 in Prof. Andreas Weigert’s Lab in Frankfurt, Germany, working on interleukin (IL)-38. After a short postdoc in the same lab, I moved to Geneva, where I am currently pursuing my research on the biology of IL-38 in the context of inflammation and resolution of inflammation in Prof. Gaby Palmer’s Lab.
We recently demonstrated a potential role of IL-38 in the priming of pro-inflammatory macrophages during experimental autoimmune encephalomyelitis, contrasting with the anti-inflammatory effects of IL-38 described so far. Moreover, my latest study described a potential function of IL-38 during the resolution of inflammation, by modulating regulatory T cells homeostasis and activation during peritonitis. The aim of my postdoc project is now to verify and understand how IL-38 regulates inflammation in other models, including a skin inflammation model in a new mouse strain overexpressing IL-38 in the epidermis, and to understand the function of IL-38 in macrophages.