Special Article of Interest

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Special Article of Interest

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo

September 14, 2025

A recent study, “An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo,” by Yemsratch Akalu, Roosheel S. Patel, Justin Taft, Rodrigo Canas-Arranz et. al., and published in Science Translational Medicine identified 10 ISGs – out of thousands of antiviral host genes – [READ MORE]

Image of March 2025 EMBO journal cover
Members in the News

Boosting human immunology: harnessing the potential of immune organoids

July 14, 2025

Featured on the March 12, 2025 cover of EMBO Molecular Medicine, this recent publication, by Maximilian Moll and Prof. Dr. Dirk Baumjohann of the Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology at University Hospital Bonn titled, “Boosting human immunology: harnessing the potential of immune organoids” highlights scientific advances [READ MORE]

Special Article of Interest

“An Il12 mRNA-LNP adjuvant enhances mRNA vaccine induced CD8 T cell responses” published in Science Immunology

June 30, 2025

The following interview was conducted by Signals+ Editor Maialen Sebastian-delaCruz, Ph.D. A recent study by Emily Aunins, Anthony Phan et. al. from the Hunter Lab at University of Pennsylvania School of Veterinary Medicine published in Science Immunology, “An Il12 mRNA-LNP adjuvant enhances mRNA vaccine induced CD8 T cell responses” showed [READ MORE]

Scientific charts and graphs
Special Article of Interest

“Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection” published in the Journal of Experimental Medicine

April 14, 2025

The following interview was conducted by Signals+ Editor Di Yu, Ph.D. The Journal of Experimental Medicine (JEM) recently published the study by Benjamin J. Broomfield et. al. showing early, short-term inhibition of IFN-I optimizes TSCM cell differentiation. Broomfield is a Ph.D. candidate in the Joanna Groom lab at WEHI. Highlights of [READ MORE]

Immunology Group in a lab
Special Article of Interest

Challenges and Opportunities of Conducting High-Quality Research in Cytokine Biology and Immunology in Low- and Middle-Income Countries

March 3, 2025

The following perspective is by ICIS Member, Javier Mora, Ph.D., University of Costa Rica, Faculty of Microbiology. We welcome your comments and feedback, either to Prof. Mora (javierfrancisco.mora @ ucr.ac.cr) directly or to the ICIS Managing Director, Stephanie Flores (sflores @ cytokinesociety.org). Research in cytokines and immunology plays a pivotal [READ MORE]

Graphical abstract and citation of recent article from lab of Dr. Edward Chuong
Special Article of Interest

“Regulation of human interferon signaling by transposon exonization” published in Cell

February 3, 2025

The following interview was conducted by Signals+ Editor Maialen Sebastian-delaCruz, Ph.D. Connect with her on LinkedIn. A recent study by Pasquesi et al from the Chuong lab published in Cell, “Regulation of human interferon signaling by transposon exonization” showed that transposable element exonization can yield functional protein isoforms as seen for [READ MORE]

Dr. Julie Stockis, Dr. Julia Moreno-Vicente, Dr. Thomas Yip, and Dr. Tim Halim
Special Article of Interest

Cross-talk between ILC2 and Gata3high Tregs locally constrains adaptive type 2 immunity

August 5, 2024

Regulatory T cells (Tregs) are essential for resolving inflammation and maintaining immune homeostasis. How Tregs are locally regulated in inflamed niches is poorly understood, although their expression of CD4 helper T (Th) cell lineage-defining transcription factors (i.e. Gata3, Rorγt, and Tbet) tailors their regulatory function towards a specific type of [READ MORE]

Photo of Article Co-Authors Viejo-Borbolla, Jacobson, and Plückebaum
Special Article of Interest

Discovery of the first IFN-binding protein in herpes viruses reported

July 15, 2024

Viral modulation of type II interferon increases T cell adhesion and virus spread Herpes and poxviruses express viroceptors, viral proteins that bind cytokines and modulate their activity. Until now, all known viroceptors that bind interferon (IFN) have been discovered exclusively in poxviruses and inhibit IFN activity through blocking the cytokine-receptor [READ MORE]

Professor John Tregoning, Faculty of Medicine, Department of Infectious Disease, Professor in Vaccine Immunology, Imperial College London
Special Article of Interest

The Write Stuff, by Prof. John Tregoning

April 1, 2024

Image from: How do we study viruses? What is a vaccine? And why don’t viruses kill us all? We answer these questions and more in our new Coursera course “Foundations in Virology and Vaccinology”, https://ow.ly/POzX50QZs03 Prof. John Tregoning on how writing science for lay audiences strengthens writing for scientific ones Communicating [READ MORE]

Special Article of Interest

A “Tour de Force” Nature Genetics Publication by New Member Musa Mhlanga

February 5, 2024

A recent study from the Mhlanga lab published in Nature Genetics, “A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation” sheds light on an intriguing locus harboring the proinflammatory cytokine IL1b and the anti inflammatory cytokine IL37. Their study focuses on a region between these two genes that harbors SNPs associated with altered immune responses in individuals during infection. They show that this region encodes the long noncoding RNA they name AMANZI (A MAster Noncoding RNA antagoniZing Inflammation) where the common variant RS16944 resides. [READ MORE]