A recent study by Ritacco et al from the Gaudet Lab published in Molecular Cell, “The human antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction”, showed that in living cells, APOL3 couples lysosomal damage to mtDNA efflux and type I IFN production. Their [READ MORE]
A recent study by Alharbi et.al. from the Gantier Lab published in Nature Immunology, “2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity”, showed that TLR7 and TLR8 sensing is kept in check by naturally occurring 2′-O-methyl (2′-OMe)-modified ribosomal RNA fragments, avoiding autoimmune responses to host RNA in the [READ MORE]
2026 has started with good news for young interferon researchers of the Cytokine Society, as a new travel award will be established this year in the name of Robert Blackburn. It will consist of $1,000, and it is aimed at students and postdocs planning to attend Cytokines2026 meeting in Glasgow. [READ MORE]
A recent study, “An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo,” by Yemsratch Akalu, Roosheel S. Patel, Justin Taft, Rodrigo Canas-Arranz et. al., and published in Science Translational Medicine identified 10 ISGs – out of thousands of antiviral host genes – [READ MORE]
Featured on the March 12, 2025 cover of EMBO Molecular Medicine, this recent publication, by Maximilian Moll and Prof. Dr. Dirk Baumjohann of the Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology at University Hospital Bonn titled, “Boosting human immunology: harnessing the potential of immune organoids” highlights scientific advances [READ MORE]
The following interview was conducted by Signals+ Editor Maialen Sebastian-delaCruz, Ph.D. A recent study by Emily Aunins, Anthony Phan et. al. from the Hunter Lab at University of Pennsylvania School of Veterinary Medicine published in Science Immunology, “An Il12 mRNA-LNP adjuvant enhances mRNA vaccine induced CD8 T cell responses” showed [READ MORE]
The following interview was conducted by Signals+ Editor Di Yu, Ph.D. The Journal of Experimental Medicine (JEM) recently published the study by Benjamin J. Broomfield et. al. showing early, short-term inhibition of IFN-I optimizes TSCM cell differentiation. Broomfield is a Ph.D. candidate in the Joanna Groom lab at WEHI. Highlights of [READ MORE]
The following perspective is by ICIS Member, Javier Mora, Ph.D., University of Costa Rica, Faculty of Microbiology. We welcome your comments and feedback, either to Prof. Mora (javierfrancisco.mora @ ucr.ac.cr) directly or to the ICIS Managing Director, Stephanie Flores (sflores @ cytokinesociety.org). Research in cytokines and immunology plays a pivotal [READ MORE]
The following interview was conducted by Signals+ Editor Maialen Sebastian-delaCruz, Ph.D. Connect with her on LinkedIn. A recent study by Pasquesi et al from the Chuong lab published in Cell, “Regulation of human interferon signaling by transposon exonization” showed that transposable element exonization can yield functional protein isoforms as seen for [READ MORE]
Regulatory T cells (Tregs) are essential for resolving inflammation and maintaining immune homeostasis. How Tregs are locally regulated in inflamed niches is poorly understood, although their expression of CD4 helper T (Th) cell lineage-defining transcription factors (i.e. Gata3, Rorγt, and Tbet) tailors their regulatory function towards a specific type of [READ MORE]
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