Reviews of Interest

April 17, 2024 – Reviews of Interest

1. PMID: 37726402 Anti-cytokine autoantibodies: mechanistic insights and disease associations. Cheng A, Holland SM. Nat Rev Immunol. 2024 Mar;24(3):161-177. doi: 10.1038/s41577-023-00933-2. Epub 2023 Sep 19.PMID: 37726402 Review.

This review provides a comprehensive overview of the emerging field of anti-cytokine autoantibodies (ACAA), including their pathological roles, mechanisms underlying immune tolerance breakdown, and, from a clinical perspective, the heterogeneous patient responses observed with current therapeutic strategies.

2. PMID: 37923366 Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story. Bonelli M, Kerschbaumer A, Kastrati K, Ghoreschi K, Gadina M, Heinz LX, Smolen JS, Aletaha D, O’Shea J, Laurence A. Ann Rheum Dis. 2024 Jan 11;83(2):139-160. doi: 10.1136/ard-2023-223850.PMID: 37923366 Free PMC article.

This concise review provides insightful information about the basic biology of the JAK-STAT pathway and its inhibitors in the treatment of autoimmune and inflammatory diseases. It includes a comprehensive discussion of approved agents and those under investigation, along with their clinical indications and side effects.

3. PMID: 38154421 Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment.Alim LF, Keane C, Souza-Fonseca-Guimaraes F. Curr Opin Immunol. 2023 Dec 27;86:102409. doi: 10.1016/j.coi.2023.102409. Online ahead of print. PMID: 38154421

This updated review discusses the multifaceted roles of tumor necrosis factor (TNF) signaling in the tumor microenvironment, with insights on their effects on both tumor cells and immune cells.

May 5, 2023 – April 3, 2024 Reviews of Interest

PMID: 36240739

The JAK-STAT pathway at 30: Much learned, much more to do.

Philips RL, Wang Y, Cheon H, Kanno Y, Gadina M, Sartorelli V, Horvath CM, Darnell JE Jr, Stark GR, O’Shea JJ.

Cell. 2022 Oct 13;185(21):3857-3876. doi: 10.1016/j.cell.2022.09.023.PMID: 36240739 Free PMC article. Review.

PMID: 36750615

The biology of TREM receptors.

Colonna M.

Nat Rev Immunol. 2023 Feb 7:1-15. doi: 10.1038/s41577-023-00837-1. Online ahead of print.PMID: 36750615 Free PMC article. Review.

PMID: 36380021

Death by TNF: a road to inflammation.

van Loo G, Bertrand MJM.

Nat Rev Immunol. 2022 Nov 15:1-15. doi: 10.1038/s41577-022-00792-3. Online ahead of print.PMID: 36380021 Free PMC article. Review.

PMID: 36795835

The extracellular matrix and the immune system: A mutually dependent relationship.

Sutherland TE, Dyer DP, Allen JE.

Science. 2023 Feb 17;379(6633):eabp8964. doi: 10.1126/science.abp8964. Epub 2023 Feb 17.PMID: 36795835 Review.

PMID: 36516267

Targeting cytokines in inflammatory bowel disease.

Neurath MF.

Sci Transl Med. 2022 Dec 14;14(675):eabq4473. doi: 10.1126/scitranslmed.abq4473. Epub 2022 Dec 14.PMID: 36516267 Review.

PMID: 36792571

Principles of regulatory T cell function.

Dikiy S, Rudensky AY.

Immunity. 2023 Feb 14;56(2):240-255. doi: 10.1016/j.immuni.2023.01.004.PMID: 36792571 Review.

PMID: 36630916

Microenvironment-driven metabolic adaptations guiding CD8⁺ T cell anti-tumor immunity.

Park J, Hsueh PC, Li Z, Ho PC.

Immunity. 2023 Jan 10;56(1):32-42. doi: 10.1016/j.immuni.2022.12.008.PMID: 36630916 Review.

PMID: 36693907

Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders.

Stanford SM, Bottini N.

Nat Rev Drug Discov. 2023 Jan 24:1-22. doi: 10.1038/s41573-022-00618-w. Online ahead of print.PMID: 36693907 Free PMC article. Review.

PMID: 36131080

Emerging principles of cytokine pharmacology and therapeutics.

Saxton RA, Glassman CR, Garcia KC.

Nat Rev Drug Discov. 2023 Jan;22(1):21-37. doi: 10.1038/s41573-022-00557-6. Epub 2022 Sep 21.PMID: 36131080 Review.

PMCID: PMC9933837.

Engineering cytokine therapeutics.

Deckers J, Anbergen T, Hokke AM, de Dreu A, Schrijver DP, de Bruin K, Toner YC, Beldman TJ, Spangler JB, de Greef TFA, Grisoni F, van der Meel R, Joosten LAB, Merkx M, Netea MG, Mulder WJM.

Nat Rev Bioeng. 2023 Feb 16:1–18. doi: 10.1038/s44222-023-00030-y. Epub ahead of print.

PMID: 36750315

Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.

Fu J, Wu H.

Annu Rev Immunol. 2022 Feb 7. doi: 10.1146/annurev-immunol-081022-021207. Online ahead of print.PMID: 36750315 Review.

PMID: 36750317

TGF-β Regulation of T Cells.

Chen W.

Annu Rev Immunol. 2022 Feb 7. doi: 10.1146/annurev-immunol-101921-045939. Online ahead of print.PMID: 36750317 Review.

PMID: 36737597

IL-4 and IL-13: Regulators and Effectors of Wound Repair.

Allen JE.

Annu Rev Immunol. 2022 Feb 3. doi: 10.1146/annurev-immunol-101921-041206. Online ahead of print.PMID: 36737597 Review.

PMID: 36596870

STAT proteins in cancer: orchestration of metabolism.

Li YJ, Zhang C, Martincuks A, Herrmann A, Yu H.

Nat Rev Cancer. 2023 Jan 3. doi: 10.1038/s41568-022-00537-3. Online ahead of print.PMID: 36596870 Review.

PMID: 36635456

Metabolites as signalling molecules.

Baker SA, Rutter J.

Nat Rev Mol Cell Biol. 2023 Jan 12. doi: 10.1038/s41580-022-00572-w. Online ahead of print.PMID: 36635456 Review.

PMID: 36316383

New insights into activation and function of the AMPK.

Steinberg GR, Hardie DG.

Nat Rev Mol Cell Biol. 2022 Oct 31. doi: 10.1038/s41580-022-00547-x. Online ahead of print.PMID: 36316383 Review.

PMID: 36596896

T_H17 cell heterogeneity and its role in tissue inflammation.

Schnell A, Littman DR, Kuchroo VK.

Nat Immunol. 2023 Jan;24(1):19-29. doi: 10.1038/s41590-022-01387-9. Epub 2023 Jan 3.PMID: 36596896 Review.

PMID: 36473794

NF-κB dynamics in the language of immune cells.

Aqdas M, Sung MH.

Trends Immunol. 2023 Jan;44(1):32-43. doi: 10.1016/j.it.2022.11.005. Epub 2022 Dec 3.PMID: 36473794 Review.

PMID: 36710220

ADAR1 and ZBP1 in innate immunity, cell death, and disease.

Karki R, Kanneganti TD.

Trends Immunol. 2023 Jan 27:S1471-4906(23)00001-7. doi: 10.1016/j.it.2023.01.001. Online ahead of print.PMID: 36710220 Review.

PMID: 36058806

Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.

Ma S, Caligiuri MA, Yu J.

Trends Immunol. 2022 Oct;43(10):833-847. doi: 10.1016/j.it.2022.08.004. Epub 2022 Sep 1.PMID: 36058806 Review.

PMID: 35794030

Molecular links between allergy and cancer.

Lorentz A, Bilotta S, Civelek M.

Trends Mol Med. 2022 Dec;28(12):1070-1081. doi: 10.1016/j.molmed.2022.06.003. Epub 2022 Jul 4.PMID: 35794030 Review.

PMID: 36705629

STING trafficking as a new dimension of immune signaling.

Jeltema D, Abbott K, Yan N.

J Exp Med. 2023 Mar 6;220(3):e20220990. doi: 10.1084/jem.20220990. Epub 2023 Jan 27.PMID: 36705629 Free PMC article.

PMID: 35863509

TSLP, IL-33, and IL-25: Not just for allergy and helminth infection.

Stanbery AG, Shuchi Smita, Jakob von Moltke, Tait Wojno ED, Ziegler SF.

J Allergy Clin Immunol. 2022 Dec;150(6):1302-1313. doi: 10.1016/j.jaci.2022.07.003. Epub 2022 Jul 19.PMID: 35863509 Review.

PMID: 34543517

Cryo-EM structure of the IL-10 receptor complex provides a blueprint for ligand engineering.

Saxton RA, Garcia KC.

FEBS J. 2022 Dec;289(24):8032-8036. doi: 10.1111/febs.16207. Epub 2021 Sep 29.PMID: 34543517 Free PMC article. Review.

PMID: 36463491

Sounding the alarmins-The role of alarmin cytokines in asthma.

Gauvreau GM, Bergeron C, Boulet LP, Cockcroft DW, Côté A, Davis BE, Leigh R, Myers I, O’Byrne PM, Sehmi R.

Allergy. 2023 Feb;78(2):402-417. doi: 10.1111/all.15609. Epub 2022 Dec 14.PMID: 36463491 Review.