Clinical Trials, contributed by Howard A. Young
Clinical Trials

Interferon Alfa Therapy Based on Th17 Profile in Membranous Nephropathy (ALPHAGEM)

ClinicalTrials.gov ID NCT05941845 Sponsor Centre Hospitalier Universitaire de Nice Information provided by Centre Hospitalier Universitaire de Nice (Responsible Party) Study Overview – Brief Summary Membranous Nephropathy (MN) is a renal autoimmune disease mediated by autoantibodies. Current management is based on the use of immunosuppressive therapies. MN patients with a pro-inflammatory Th17 [READ MORE]

Clinical Trials, contributed by Howard A. Young
Clinical Trials

Pegylated Interferon α-2b in Combination With Ruxolitinib for Treating Hydroxyurea-resistant/Intolerant PV (PV)

ClinicalTrials.gov ID NCT05870475 Sponsor Institute of Hematology & Blood Diseases Hospital, China Information provided by Institute of Hematology & Blood Diseases Hospital, China (Responsible Party) Study Overview – Brief Summary Study purpose: To compare the efficacy and safety of pegylated interferon α-2b in combination with ruxolitinib versus pegylated interferon α-2b alone [READ MORE]

Clinical Trials, contributed by Howard A. Young
Clinical Trials

Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU Patients (IGNORANT)

ClinicalTrials.gov ID NCT05843786 Sponsor Hospices Civils de Lyon Information provided by Hospices Civils de Lyon (Responsible Party) Study Overview – Brief Summary Clinical presentation of patients after severe injury such as a severe infection, trauma or extensive burns is characterized by the simultaneous occurrence of dysregulation of the initial inflammatory response [READ MORE]

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Clinical Trials

Early Interferon-beta Treatment for West-Nile Virus Infection

ClinicalTrials.gov ID NCT06510426 Sponsor Tel-Aviv Sourasky Medical Center Study Overview – Brief Summary West Nile virus (WNV) is a mosquito-borne virus which in majority of cases causes only self-limited disease. Despite that, in minority of cases (~0.5%) it can infect the brain and cause severe and even life-threatening disease (neuroinvasive disease). [READ MORE]

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Clinical Trials

Safety and Efficacy of Interferon-Gamma 1b in Patients with Candidemia

ClinicalTrials.gov ID NCT04979052 Sponsor Radboud University Medical Center Study Overview – Brief Summary A multi-center open label adaptive randomized interventional phase 2 study to evaluate safety and efficacy of rIFN-y treatment in patients with candidemia. Detailed Description A multi-center open label adaptive randomized interventional phase 2 study to evaluate safety [READ MORE]

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Clinical Trials

Interferon Alpha Therapy for Cervical CINI and HPV Infection

ClinicalTrials.gov ID NCT06137950 Sponsor Mongolian National University of Medical Sciences Study Overview – Brief Summary Mongolia is a traditionally nomadic and population is scarce in rural areas. Thus, the medical care service is not sufficient. In 2000, Mongolian government has developed and implemented the millennium project in cooperation with WHO. [READ MORE]

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Clinical Trials

Recombinant Interleukin-15

Recombinant Interleukin-15 in Combination With Checkpoint Inhibitors Nivolumab and Ipilimumab in People With Refractory Cancers ClinicalTrials.gov ID NCT03388632 Sponsor National Cancer Institute (NCI) Information provided by National Institutes of Health Clinical Center (CC) (National Cancer Institute (NCI)) (Responsible Party)

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Clinical Trials

Role of IL-5R Signaling

Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP (RECAP-5) ClinicalTrials.gov ID NCT05672030 Sponsor Brigham and Women’s Hospital Information provided by Tanya Laidlaw, MD, Brigham and Women’s Hospital (Responsible Party)

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Clinical Trials

Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia

ClinicalTrials.gov ID NCT05600920 Sponsor National Institute of Allergy and Infectious Diseases (NIAID) Information provided by National Institutes of Health Clinical Center (CC) (National Institute of Allergy and Infectious Diseases (NIAID)) Study Overview Brief Summary Background: Idiopathic CD4 lymphopenia (ICL) is a syndrome characterized by low levels of certain immune cells [READ MORE]